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1

An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart

Qi-Zhi Chen, Hikaru Ishii, George A. Thouas, Alexander R. Lyon, Jamie S. Wright, Jonny J. Blaker, Wojciech Chrzanowski, Aldo R. Boccaccini, Nadire N. Ali, Jonathan C. Knowles, Siân E. Harding

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2010

2

Embryonic stem cell-derived cardiomyocytes as a model to study fetal arrhythmia related to maternal disease

Siti H. Sheikh Abdul Kadir, Nadire N. Ali, Maxime Mioulane, Marta Brito-Martins, Shadi Abu-Hayyeh, Gabor Foldes, Alexey V. Moshkov, Catherine Williamson, Sian E. Harding, Julia Gorelik

Journal:

Journal of Cellular and Molecular Medicine

Année:

2009

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2009

3

The use of embryonic stem cell-derived cardiomyocytes as a model to study fetal arrhythmia related to maternal disease

Siti Hamimah Sheikh Abdul Kadir, Nadire N. Ali, Shadi Abu-Hayyeh, Sian E. Harding, Catherine Williamson, Julia Gorelik

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 62 KB

english, 2008

4

Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning

Lyon, Alexander R, Rees, Paul SC, Prasad, Sanjay, Poole-Wilson, Philip A, Harding, Sian E

Journal:

Nature Clinical Practice Cardiovascular Medicine

Année:

2008

Langue:

english

Fichier:

PDF, 300 KB

english, 2008

5

Estrogen deficiency compromised the β2AR-Gs/Gi coupling: implications for arrhythmia and cardiac injury

Hou, Hongjian, Zhao, Zhiwei, Machuki, Jeremiah Ong’achwa, Zhang, Lin, Zhang, Yan, Fu, Lu, Wu, Jinxia, Liu, Yuyu, Harding, Sian E., Sun, Hong

Journal:

Pflügers Archiv European Journal of Physiology

Année:

2018

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2018

6

Specific β 2 AR Blocker ICI 118,551 Actively Decreases Contraction Through a G i -Coupled Form of the β 2 AR in Myocytes From Failing Human Heart

Gong, Haibin, Sun, Hong, Koch, Walter J., Rau, Thomas, Eschenhagen, Thomas, Ravens, Ursula, Heubach, Jürgen F., Adamson, Dawn L., Harding, Sian E.

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 147 KB

english, 2002

7

Future potential of engineered heart tissue patches for repairing the damage caused by heart attacks

Jabbour, Richard J., Owen, Thomas J., Pandey, Pragati, Harding, Sian E.

Journal:

Expert Review of Medical Devices

Année:

2019

Fichier:

PDF, 575 KB

2019

8

Nanocomposite Elastomeric Biomaterials for Myocardial Tissue Engineering Using Embryonic Stem Cell-derived Cardiomyocytes

Hedeer Jawad, Miroslawa El Fray, Aldo R. Boccaccini, Sian E. Harding, Jamie S. Wright, Qizhi Chen, Agnieszka Piegat, Nadire N. Ali

Journal:

Advanced Engineering Materials

Année:

2010

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2010

9

Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue

Qi-Zhi Chen, Alexander Bismarck, Ulrich Hansen, Sarah Junaid, Michael Q. Tran, Siân E. Harding, Nadire N. Ali, Aldo R. Boccaccini

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 725 KB

english, 2008

10

Biomaterials in cardiac tissue engineering: Ten years of research survey

Qi-Zhi Chen, Siân E. Harding, Nadire N. Ali, Alexander R. Lyon, Aldo R. Boccaccini

Journal:

Materials Science and Engineering: R: Reports

Année:

2008

Langue:

english

Fichier:

PDF, 2.55 MB

english, 2008

11

Phosphodiesterase inhibition and Ca2+sensitization

Ursula Ravens, Herbert M. Himmel, Michael Flüss, Kerry Davia, Sian E. Harding

Journal:

Molecular and Cellular Biochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 458 KB

english, 1996

12

Cardiostimulant and cardiodepressant effects through overexpressed human β2-adrenoceptors in murine heart: regional differences and functional role of β1-adrenoceptors

Jürgen F. Heubach, Marianne Blaschke, Sian E. Harding, Ursula Ravens, Alberto J. Kaumann

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 323 KB

english, 2003

13

Rp-cAMPS has ho effect on adenosine A1receptors in guinea-pig cardiomyocytes

Dawn L. Adamson, Sian E. Harding

Journal:

Basic Research in Cardiology

Année:

2000

Langue:

english

Fichier:

PDF, 78 KB

english, 2000

14

Cardiac Stem Cell Therapy and Arrhythmogenicity: Prometheus and the arrows of Apollo and Artemis

Alexander R. Lyon, Sian E. Harding, Nicholas S. Peters

Journal:

Journal of Cardiovascular Translational Research

Année:

2008

Langue:

english

Fichier:

PDF, 195 KB

english, 2008

15

Are there functional β3-adrenoceptors in the human heart?

Martin C Michel, Sian E Harding, Richard A Bond

Journal:

British Journal of Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 290 KB

english, 2011

16

Human stem cell-derived cardiomyocytes for pharmacological and toxicological modeling

Sian E. Harding

Journal:

Annals of the New York Academy of Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 444 KB

english, 2011

17

The effect of Gi-protein inactivation on basal, and β1- and β2AR-stimulated contraction of myocytes from transgenic mice overexpressing the β2-adrenoceptor

Haibin Gong, Dawn L Adamson, Hardeep K Ranu, Walter J Koch, Jürgen F Heubach, Ursula Ravens, Oliver Zolk, Sian E Harding

Journal:

British Journal of Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 194 KB

english, 2000

18

Murine ventricular L-type Ca2+ current is enhanced by zinterol viaβ1-adrenoceptors, and is reduced in TG4 mice overexpressing the human β2-adrenoceptor

Jürgen F Heubach, Eva M Graf, Peter Molenaar, Andreas Jäger, Frank Schröder, Stefan Herzig, Sian E Harding, Ursula Ravens

Journal:

British Journal of Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 253 KB

english, 2001

19

Overexpression of β1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for ‘putative’β4-adrenoceptor pharmacology

Clive J Lewis, Haibin Gong, Morris J Brown, Sian E Harding

Journal:

British Journal of Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 290 KB

english, 2004

20

Effect of overexpressed adenylyl cyclase VI on β1- and β2-adrenoceptor responses in adult rat ventricular myocytes

Joalice C C Stark, Stephen F Haydock, Roger Foo, Morris J Brown, Sian E Harding

Journal:

British Journal of Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 327 KB

english, 2004

21

Iron Particles for Noninvasive Monitoring of Bone Marrow Stromal Cell Engraftment into, and Isolation of Viable Engrafted Donor Cells from, the Heart

Daniel J. Stuckey, Carolyn A. Carr, Enca Martin-Rendon, Damian J. Tyler, Corinne Willmott, Paul J. Cassidy, Sarah J.M. Hale, Jürgen E. Schneider, Louise Tatton, Sian E. Harding, George K. Radda, Suzan

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 667 KB

english, 2006

22

A Novel ADP/ATP Transporter in the Mitosome of the Microaerophilic Human Parasite Entamoeba histolytica

Ka Wai Chan, Dirk-Jan Slotboom, Sian Cox, T. Martin Embley, Olivier Fabre, Mark van der Giezen, Marilyn Harding, David S. Horner, Edmund R.S. Kunji, Gloria León-Avila, Jorge Tovar

Journal:

Current Biology

Année:

2005

Langue:

english

Fichier:

PDF, 570 KB

english, 2005

23

The human embryonic stem cell-derived cardiomyocyte as a pharmacological model

Sian E. Harding, Nadire N. Ali, Marta Brito-Martins, Julia Gorelik

Journal:

Pharmacology & Therapeutics

Année:

2007

Langue:

english

Fichier:

PDF, 856 KB

english, 2007

24

β-Adrenoceptor Blockers as Agonists: Coupling of β2-Adrenoceptors to Multiple G-Proteins in the Failing Human Heart

Sian E. Harding, Haibin Gong

Journal:

Congestive Heart Failure

Année:

2004

Langue:

english

Fichier:

PDF, 282 KB

english, 2004

25

Multi-centred mixed-methods PEPFAR HIV care & support public health evaluation: study protocol

Richard Harding, Victoria Simms, Suzanne Penfold, Paul McCrone, Scott Moreland, Julia Downing, Richard A Powell, Faith Mwangi-Powell, Eve Namisango, Peter Fayers, Siân Curtis, Irene J Higginson

Journal:

BMC Public Health

Année:

2010

Langue:

english

Fichier:

PDF, 701 KB

english, 2010

26

The Effect of Alterations to Action Potential Duration on β-Adrenoceptor-Mediated Aftercontractions in Human and Guinea-pig Ventricular Myocytes

David Tweedie, Peter O»Gara, Sian E. Harding, Kenneth T. MacLeod

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1997

Langue:

english

Fichier:

PDF, 364 KB

english, 1997

27

The Role of Gi-proteins andβ-Adrenoceptors in the Age-related Decline of Contraction in Guinea-pig Ventricular Myocytes

Nicola Ferrara, Michael Bö, Oliver Zolk, Peter O»Gara, Sian E. Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1997

Langue:

english

Fichier:

PDF, 443 KB

english, 1997

28

Sarcoplasmic Reticulum Ca Content, Sarcolemmal Ca Influx and the Genesis of Arrhythmias in Isolated Guinea-pig Cardiomyocytes

David Tweedie, Sian E. Harding, Kenneth T. MacLeod

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2000

Langue:

english

Fichier:

PDF, 192 KB

english, 2000

29

Functional Evidence for a Cyclic-AMP Related Mechanism of Action of the β2-adrenoceptor in Human Ventricular Myocytes

Dawn L Adamson, Andrew R.W Money-Kyrle, Sian E Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2000

Langue:

english

Fichier:

PDF, 137 KB

english, 2000

30

SERCA2a Overexpression Decreases the Incidence of Aftercontractions in Adult Rabbit Ventricular Myocytes

Kerry Davia, Elena Bernobich, Hardeep K. Ranu, Federica del Monte, Cesare M.N. Terracciano, Kenneth T. MacLeod, Dawn L. Adamson, Babar Chaudhri, Roger J. Hajjar, Sian E. Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2001

Langue:

english

Fichier:

PDF, 242 KB

english, 2001

31

Effects of Na+/Ca2+-exchanger Overexpression on Excitation–contraction Coupling in Adult Rabbit Ventricular Myocytes

Hardeep K. Ranu, Cesare M.N. Terracciano, Kerry Davia, Elena Bernobich, Babar Chaudhri, Susan E. Robinson, Zhao Bin Kang, Roger J. Hajjar, Kenneth T. MacLeod, Sian E. Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2002

Langue:

english

Fichier:

PDF, 206 KB

english, 2002

32

Contamination of a cardiac sarcolemmal preparation with endothelial plasma membrane

Barbara Tomlins, Sian E. Harding, Mark S. Kirby, Philip A. Poole-Wilson, Alan J. Williams

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

1986

Langue:

english

Fichier:

PDF, 595 KB

english, 1986

33

The application of high pressure liquid chromatography to the analysis of bile salts in human bile

M.S. Sian, A.J.Harding Rains

Journal:

Clinica Chimica Acta

Année:

1979

Langue:

english

Fichier:

PDF, 736 KB

english, 1979

34

An antiadrenergic effect of adenosine on guinea-pig but not rabbit ventricles

Alexandra M. Hopwood, Sian E. Harding, Peter Harris

Journal:

European Journal of Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 657 KB

english, 1987

35

Pertussis toxin reduces the antiadrenergic effect of 2-chloroadenosine on papillary muscle and the direct negative inotropic effect of 2-chloroadenosine on atrium

Alexandra M. Hopwood, Sian E. Harding, Peter Harris

Journal:

European Journal of Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 404 KB

english, 1987

36

Contraction of cardiac myocytes from noradrenaline-treated rats in response to isoprenaline, forskolin and dibutyryl cAMP

S.Mary Jones, Nicholas A. Hunt, Federica Del Monte, Sian E. Harding

Journal:

European Journal of Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1990

37

Reduced contractile responses to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle

Sian E. Harding, S. Mary Jones, Giorgio Vescovo, Federica Del Monte, Philip A. Poole-Wilson

Journal:

European Journal of Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1992

38

Cyclic AMP levels in ventricular myocytes from noradrenaline-treated guinea-pigs

Dylan G. Wynne, Federica Del Monte, Sian E. Harding

Journal:

European Journal of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 825 KB

english, 1996

39

Comparison of inhibitory G-protein effects in human, guinea-pig and rat isolated ventricular myocytes

Lesley A Brown, Sian E Harding, Philip A Poole-Wilson

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1990

Langue:

english

Fichier:

PDF, 103 KB

english, 1990

40

Correlation between contractile response to isoprenaline in human left ventricular myocytes and indicators of heart failure

Sian E. Harding, Nicholas A. Hunt, S.Mary Jones, Peter O'Gara, Philip A. Poole-Wilson

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1990

Langue:

english

Fichier:

PDF, 95 KB

english, 1990

41

Interaction between phosphodiesterase inhibitors and isoprenaline in myocytes from beta-receptor-desensitised human and guinea-pig hearts

Dylan G. Wynne, Peter O'Gara, Sian E. Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1991

Langue:

english

Fichier:

PDF, 109 KB

english, 1991

42

β-adrenoceptor desensitisation, and its reversal by pertussis toxin, in myocytes isolated from noradrenaline treated guinea-pig hearts

Lesley A. Brown, Sian E. Harding, Philip A. Poole-Wilson

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1991

Langue:

english

Fichier:

PDF, 107 KB

english, 1991

43

Reduced response to camp analogues in myocytes from noradrenaline-treated guinea-pig and failing human heart; Reversal by pertussis toxin

Sian E Harding, Lesley A Brown, Giorgio Vescovo, Federica del Monte, Philip A Poole-Wilson

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1992

Langue:

english

Fichier:

PDF, 102 KB

english, 1992

44

Effects of endothelin-1 on contractile responses and phosphatidylinositol hydrolysis in isolated myocytes from guinea-pig and rat heart

Federica del Monte, John R Mynett, Peter H Sugden, Philip A Poole-Wilson, Sian E Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1992

Langue:

english

Fichier:

PDF, 88 KB

english, 1992

45

Inhibition of nitric oxide synthase reverses the depressed contraction of cardiac myocytes isolated from endotoxin treated guinea-pigs

Adrian JB Brady, Philip A Poole-Wilson, Sian E Harding, John B Warren

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1992

Langue:

english

Fichier:

PDF, 109 KB

english, 1992

46

Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response

Sian E. Harding, S.Mary Jones, Peter O'Gara, Federica del Monte, Giorgio Vescovo, Philip A. Poole-Wilson

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1992

Langue:

english

Fichier:

PDF, 1.70 MB

english, 1992

47

Decreased contractile responses to isoproterenol in isolated cardiac myocytes from ageing guinea-pigs

Nicola Ferrara, Peter O'Gara, Dylan G Wynne, Lesley A Brown, Federica del Monte, Philip A Poole-Wilson, Sian E Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1995

Langue:

english

Fichier:

PDF, 842 KB

english, 1995

48

The potential of cardiac stem cell therapy for heart failure

Alexander Lyon, Sian Harding

Journal:

Current Opinion in Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 150 KB

english, 2007

49

Loss of β-adrenoceptor response in myocytes overexpressing the Na+/Ca2+-exchanger

Motoki Sato, Haibin Gong, Cesare M.N. Terracciano, Hardeep Ranu, Sian E. Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2004

Langue:

english

Fichier:

PDF, 367 KB

english, 2004

50

Modelling GPCR effects in the cardiomyocyte: A bridge from reconstituted systems to human heart

Sian E. Harding

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2005

Langue:

english

Fichier:

PDF, 87 KB

english, 2005